Novel Science

Cirmtuzumab (anti-ROR1 mAB)

Publications

A drive through cellular therapy for CLL in 2015: allogeneic cell transplantation and CARs. Mato, A. & Porter, D. (2015) Blood 126(4); 478-485  

Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Choi, M., et al. (2015) Clinical Lymphoma, Myeloma & Leukemia 15(S1); S167-S169

Targeting ROR1 Inhibits Epithelial–Mesenchymal Transition and Metastasis. Cui, B., et al. (2015) Cancer Research 73(12); 3649-3660 

Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation. Yu, J., et al. (2015) Journal of Clinical Investigation 10(1172); 1-34 

ROR1, an embryonic protein with an emerging role in cancer biology. Borcherding, N., et al. (2014) Protein Cell 5(7); 496-502 

The Onco-Embryonic Antigen ROR1 Is Expressed by a Variety of Human Cancers. Zhang, S., et al. (2012) The American Journal of Pathology 181(6); 1903-1910

The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Hudecek, M., et al. (2010) Blood 116(22); 4532-4541

Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations. Deniger, D., et al. (2015) PLoS ONE 10(6); 1-19

Presentations

Immunotherapeutic Targeting of ROR1-Dependent, Non-Canonical Wnt5a-Signaling By Cirmtuzumab: A First-in-Human Phase I Trial for Patients with Intractable Chronic Lymphocytic Leukemia. Choi, M., et al. American Society of Hematology Annual Meeting Poster, December 2016. Available upon request.

Cirmtuzumab Targets ROR1 to Inhibit Ibrutinib-Resistant, Wnt5a-Induced Rac1 Activation in Chronic Lymphocytic Leukemia. Yu, J., et al. American Society of Hematology Annual Meeting Poster, December 2016. Available upon request.

Wnt5a Induces ROR1 to Complex with HS1, Which Undergoes Tyrosine Phosphorylation and Contributes to Planar-Cell-Polarity Migration in Chronic Lymphocytic Leukemia. Hasan, K., et al. American Society of Hematology Annual Meeting Poster, December 2016. Available upon request.

Wnt5a Induces Association of ROR1 with 14-3-3ζ to Enhance Chemotaxis and Proliferation in Chronic Lymphocytic Leukemia.Yu, J., et al. American Society of Hematology Annual Meeting Poster, December 2016.Available upon request.