Product Pipeline

Preclinical Programs

In addition to our current clinical programs, we’re actively evaluating opportunities to advance our two pipeline products into additional clinical trials. Both ROR1 and the ets-family transcription protein are highly expressed in multiple cancers. We are also investing in R&D to support additional modalities for targeting ROR1 as well as an ongoing research programs at UCSD and Georgetown University. Our academic collaborations further strengthen both of these programs.

We are enrolling patients:

  • With B-Cell Lymphoid Malignancies (chronic lymphocytic leukemia and mantle cell lymphoma) for a Phase 1b/2 study of cirmtuzumab in combination with ibrutinib
  • With HER2 negative, metastatic breast cancer for a Phase 1b study of cirmtuzumab in combination with paclitaxel
  • With Ewing sarcoma for a Phase 1 study of TK216, our small-molecule inhibitor of ETS-family transcription factor oncoproteins, in combination with vincristine
Participate in Our Trials